Anti-Human/Mouse HDAC1 (Clone 10E2) - Biotin - 50 µg

IF Microscopy, IF Staining, IP, WB, Chromatin IP (ChIP)

2 - 8°C Wet Ice

HDAC1 is a histone deacetylase that plays an important role in transcriptional regulation, cellcycle progression, and development1 as well as regulates major endothelial functions such asangiogenesis, inflammatory signalling, redox homeostasis, and nitric oxide signalling2. As partof a large multiprotein complex, HDAC1 deacetylates lysine residues on the N-terminal portionof core histones H2A, H2B, H3 and H41. In this capacity, HDAC1 is involved in chromatinremodelling, histone acetylation, and RNA polymerase II progression in transcribed regions.Additionally, HDAC1 deacetylates non-histone targets (NR1D2, RELA, SP1, SP3, STAT3, RELA, TSHZ3, SP proteins), and thereby regulates their function. HDAC1 is also required forrepression of circadian genes (CLOCK-BMAL-1, PER1, and CRY1). Knockout of HDAC1 inmice causes impairment to cellular proliferation and death at embryonic day 9.53.

0.5 mg/ml

HDAC1 expression is ubiquitous, with higher levels in heart, pancreas, andtestis tissues. Levels are lower in kidney and brain. HDAC1 primarily localizes to the nucleus.