Anti-Human/Mouse HDAC2 (Clone 3f3) - Biotin - 50 µg

ICFC, IHC FFPE, WB, Chromatin IP (ChIP)

2 - 8°C Wet Ice

Histone modifications are essential to cellular differentiation and proliferation throughout growthand development1. Histone deacetylases induce changes in chromatin structure that enableepigenetic control and modulation of gene expression patterns. Histone deacetylase 2 (HDAC2)is a class I histone deacetylase that, along with HDAC1, regulates gene expression as part of acorepressor complex. HDAC2 catalyzes the deacetylation of lysine residues on the N-terminus ofcore histones H2A, H2B, H3 and H42. HDAC2 can also perform noncatalytic activities1.Additionally, HDAC2 associates with F-actin in mitotic cells3. HDAC inhibitors are beinginvestigated for the treatment of neurological diseases and cancer1. 3F3 was generated by immunizing mice with a KLH-conjugated, synthetic peptidecorresponding to the carboxy terminus of human HDAC2, amino acids 473-488.

0.5 mg/ml

HDAC2 is widely expressed, with lower levels present in the brain andlung.