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BAY-876

BAY-876

Item no.	HY-100017-10mM
Manufacturer	MedChem Express
CASRN	1799753-84-6
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 2 mg 50 mg 5 mg
Category	Metabolism Diabetes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.67
Citations	[1]Siebeneicher H et al. Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. ChemMedChem. 2016 Aug 23.\|[2]Ma Y, et al. Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876. Cancers (Basel). 2018 Dec 31;11(1).\|[3]Zhang R, et al. Reductive cell death: the other side of the coin[J]. Cancer Gene Therapy, 2023, 30(7): 929-931.
Smiles	O=C(C1=NC2=CC(F)=CC=C2C(C(NC3=C(C)N(CC4=CC=C(C#N)C=C4)N=C3C(F)(F)F)=O)=C1)N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1799753-84-6
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Disulfidptosis; GLUT
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	496.42
Product Description	BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 100 mg/mL\|Methanol: 1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Membrane Transporter/Ion Channel
Isoform	GLUT1; GLUT2; GLUT3; GLUT4
Clinical information	No Development Reported

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HY-100017-10mM-safety-datasheet.pdf