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Flavopiridol (Hydrochloride)

Flavopiridol (Hydrochloride)

Item no.	HY-10006-50mg
Manufacturer	MedChem Express
CASRN	131740-09-5
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Breast Cancer Brain Cancer
Type	Inhibitors
Specific against	other
Purity	99.73
Citations	[1]Mahoney E, et al. ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.Blood. 2012 Aug 9;120(6):1262-1273.\|[2]Keskin H, et al. Complex effects of flavopiridol on the expression of primary response genes. Cell Div. 2012 Mar 29;7:11.\|[3]Kim KS, et al.Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects. J Med Chem. 2000 Nov 2;43(22):4126-34. Cancer Discov. 2021 Oct 6;candisc.1848.2020.\|Cell Commun Signal. 2022 Sep 5;20(1):96.\|Nat Commun. 2024 Dec 5;15(1):10594.\|Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):e2115667118.\|Research Square Preprint. 2024 May 2.\|ACS Chem Biol. 2017 May 19;12(5):1245-1256.\|Acta Pharm Sin B. 26 February 2022.\|Biochem Biophys Res Commun. 2019 Jun 11;513(4):967-973.\|Biomaterials. 2014 Aug;35(24):6585-94. \|bioRxiv. 2023 Sep 7.\|bioRxiv. 2024 July 27.\|bioRxiv. 2024 Mar 17.\|bioRxiv. 2024 Sep 29:2024.09.28.615444.\|Cancers (Basel). 2022 Mar 19;14(6):1575.\|Cell Chem Biol. 2018 Feb 15;25(2):135-142.e5.\|Cell Chem Biol. 2019 Aug 15;26(8):1067-1080.e8. \|Cell Mol Life Sci. 2020 May 21.\|Cell Rep. 2020 Apr 28;31(4):107586.\|Cell Syst. 2018 Apr 25;6(4):424-443.e7.\|Cell. 2021 Apr 15;184(8):2167-2182.e22.\|Clin Cancer Res. 2020 Apr 15;26(8):2011-2021. \|EMBO Rep. 2022 Apr 11;e53932.\|Free University of Berlin. Gedruckt mit Genehmigung des Fachbereichs Veterinärmedizin. 2021 Mar.\|Harvard Medical School LINCS LIBRARY\|Int J Biol Sci. 2023 Aug 6;19(13):4123-4138.\|iScience. 2024 May 16.\|J Med Chem. 2021 Mar 11;64(5):2725-2738.\|Molecules. 2023 Mar 4.\|Nature. 2024 Apr;628(8007):408-415.\|PLoS Genet. 2024 Jun 3;20(6):e1011308.\|Purdue University. Department of Chemistry.\|Research Square Preprint. 2022 Jan.\|Research Square Preprint. 2024 Apr 2.\|School of Medicine, Department of Pharmacology. 2020 Jun.\|Sci Data. 2024 Sep 19.\|Sci Rep. 2015 Dec 1;5:17675. \|Sci Rep. 2021 Mar 8;11(1):5374.\|Sci Rep. 2024 Oct 31;14(1):26239.\|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.\|The University of Chicago. Biological Sciences Division Pritzker School of Medicine. 2022 Aug.\|Toxicol Lett. 2024 Sep 12:S0378-4274(24)02025-3.\|Turk Neurosurg. 2016;26(6):922-929.
Smiles	O=C1C2=C(C=C(C([C@]3([H])[C@H](O)CN(C)CC3)=C2OC(C4=CC=CC=C4Cl)=C1)O)O.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Alvocidib (Hydrochloride),L86-8275 (Hydrochloride),HMR-1275 (Hydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Autophagy; CDK; HIV
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	438.30
Product Description	Flavopiridol Hydrochloride (Alvocidib Hydrochloride) is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively.
Manufacturer - Research Area	Cancer
Solubility	DMF: 7.69 mg/mL (ultrasonic)\|DMSO: ≥ 20 mg/mL\|H2O: ≥ 20 mg/mL
Manufacturer - Pathway	Anti-infection; Autophagy; Cell Cycle/DNA Damage
Isoform	CDK1; CDK2; CDK4
Clinical information	Phase 2

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HY-10006-50mg-safety-datasheet.pdf