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SCH 546738

SCH 546738

Item no.	HY-10017-50mg
Manufacturer	MedChem Express
CASRN	906805-42-3
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Food Safety Antibiotics Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules Stem Cell Markers
Type	Inhibitors
Specific against	other
Purity	98.71
Citations	[1]Jenh CH, et al. A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection. BMC Immunol. 2012 Jan 10;13:2.\|[2]Zhang X, et al. CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy. J Hepatol. 2016 Jan;64(1):160-70.\|[3]Yue C, et al. STAT3 in CD8<sup>+</sup> T Cells Inhibits Their Tumor Accumulation by Downregulating CXCR3/CXCL10 Axis. Cancer Immunol Res. 2015 Aug;3(8):864-870.
Smiles	O=C(N)C1=NC(Cl)=C(N2CCN(C3CCN(CC4=CC=C(Cl)C=C4)CC3)[C@@H](CC)C2)N=C1N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	906805-42-3
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	CXCR
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	492.44
Product Description	SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments.
Manufacturer - Research Area	Inflammation/Immunology; Endocrinology
Solubility	DMSO: 2.5 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein; Immunology/Inflammation
Isoform	CXCR3
Clinical information	No Development Reported

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HY-10017-50mg-safety-datasheet.pdf