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PF-04991532

PF-04991532

Item no.	HY-100181-10mg
Manufacturer	MedChem Express
CASRN	1215197-37-7
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Metabolism Diabetes Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.42
Citations	[1]Erion DM, et al. The hepatoselective glucokinase activator PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis in diabetic rats. PLoS One. 2014 May 23;9(5):e97139.
Smiles	O=C(C1=CC=C(NC([C@@H](N2C=C(C(F)(F)F)N=C2)CC3CCCC3)=O)N=C1)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1215197-37-7
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Glucokinase
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	396.36
Product Description	PF-04991532 is a potent, hepatoselective glucokinase activator with EC50s of 80 and 100 nM in human and rat, respectively.
Manufacturer - Research Area	Metabolic Disease
Solubility	DMSO: 250 mg/mL (ultrasonic)
Manufacturer - Pathway	Metabolic Enzyme/Protease
Clinical information	Phase 2

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-100181-10mg-safety-datasheet.pdf