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CA-074 methyl ester

CA-074 methyl ester

Item no.	HY-100350-5mg
Manufacturer	MedChem Express
CASRN	147859-80-1
Amount	5 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 25 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Molecular Targets for Neuroscience Neural Signaling Protein Aggregation, Clearance & Misfolding Inhibitors & Compound Libraries Small Molecules By Organ Lymphatic System Cancer Neuronal Cell Markers
Type	Inhibitors
Specific against	other
Purity	99.62
Citations	[1]Xu Y, et al. Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats. Brain Res Bull. 2016 Jan;120:97-105\|[2]Patel N, et al. CA-074Me compound inhibits osteoclastogenesis via suppression of the NFATc1 and c-FOS signaling pathways. J Orthop Res. 2015 Oct;33(10):1474-86\|[3]Zhang L, et al. Treatment with CA-074Me, a Cathepsin B inhibitor, reduces lung interstitial inflammation and fibrosis in a rat model of polymyositis. Lab Invest. 2015 Jan;95(1):65-77
Smiles	O=C([C@@H]1[C@@H](C(NCCC)=O)O1)N[C@]([C@@H](C)CC)([H])C(N(CCC2)[C@@H]2C(OC)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CA-074Me
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Cathepsin
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	397.47
Product Description	CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.
Manufacturer - Research Area	Neurological Disease; Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Metabolic Enzyme/Protease
Isoform	Cathepsin B
Clinical information	No Development Reported

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HY-100350-5mg-safety-datasheet.pdf