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Eltanexor

Eltanexor

Manufacturer	MedChem Express
Category	Oncology Neuroscience Neural Mitochondrial Function Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Amount	10mM/1mL
Item no.	HY-100423-10mM
CASRN	1642300-52-4
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	Eltanexor (KPT-8602) is a second-generation, highly specific and orally active exportin-1 (XPO1) inhibitor with potent anti-leukemic activity. Eltanexor (KPT-8602) inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor (KPT-8602) induces Caspase-dependent apoptosis in a panel of leukemic cell lines[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	428.29
Clinical_Information	Phase 2
Manufacturers Research_Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL
Manufacturers Target	CRM1
Pathway	Membrane Transporter/Ion Channel
Manufacturers Product type	Reference compound

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