C29

Item no.	HY-100461-10mg
Manufacturer	MedChem Express
CASRN	363600-92-4
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules Neurodegeneration Markers
Type	Inhibitors
Specific against	other
Purity	98.00
Citations	[1]Mistry P, et al. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5455-60.\|[2]Cai S, Zhu G, Cen X, et al. Synthesis, structure-activity relationships and preliminary mechanism study of N-benzylideneaniline derivatives as potential TLR2 inhibitors. Bioorg Med Chem. 2018;26(8):2041-2050.
Smiles	OC1=C(/C=N/C2=C(C)C(C(O)=O)=CC=C2)C=CC=C1OC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	363600-92-4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Toll-like Receptor (TLR)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	285.29
Product Description	C29 is a Toll-like receptor 2 (TLR2) inhibitor. C29 blocks hTLR2/1 and hTLR2/6 signaling with IC50s of 19.7 and 37.6 μM, respectively[1].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: ≥ 30 mg/mL
Manufacturer - Pathway	Immunology/Inflammation
Isoform	TLR2
Clinical information	No Development Reported

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HY-100461-10mg-safety-datasheet.pdf