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APS-2-79

APS-2-79

Item no.	HY-100627-5mg
Manufacturer	MedChem Express
CASRN	2002381-25-9
Amount	5 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Neuroscience Protein Aggregation, Clearance & Misfolding Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.38
Citations	[1]Dhawan NS, et al. Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling. Nature. 2016 Aug 24;537(7618):112-116.
Smiles	CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=NC=NC4=CC(OC)=C(OC)C=C43
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2002381-25-9
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	MEK
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	387.43
Product Description	APS-2-79 is a KSR-dependent MEK antagonist. APS-2-79 inhibits ATPbiotin binding to KSR2 within the KSR2-MEK1 complexe with an IC50 of 120 nM. APS-2-79 makes the stabilization of the KSR inactive state antagonizes oncogenic Ras-MAPK signaling[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO : 20 mg/mL (ultrasonic)
Manufacturer - Pathway	MAPK/ERK Pathway
Clinical information	No Development Reported
Isoform	MEK1

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