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Y-33075

Y-33075

Item no.	HY-10067-10mg
Manufacturer	MedChem Express
CASRN	199433-58-4
Amount	10 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Oncology Food Safety Histamines Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Specific against	other
Purity	99.19
Citations	[1]Hideki Tokushige, et al. Effects of Topical Administration of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Ocular Tissues in Rabbits and Monkeys Invest. Ophthalmol. Vis. Sci. July 2007 vol. 48no. 7 3216-3222\|[2]Tokushige H, et al. Effects of Y-39983, a selective Rho-associated protein kinase inhibitor, on blood flow in optic nerve head in rabbits and axonal regeneration of retinal ganglion cells in rats. Curr Eye Res. 2011 Oct;36(10):964-70.\|[3]Watabe H, et al. Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries.Jpn J Ophthalmol. 2011 Jul;55(4):411-7. Epub 2011 Jun 11. Acta Neuropathol Commun. 2024 Sep 14;12(1):150.\|Cell Death Dis. 2024 Dec 26;15(12):932.\|Cells. 2024 Nov 18;13(22):1907.\|J Cell Physiol. 2021 Jun 27.\|Patent. US20170349879A1.\|PLoS One. 2023 Jan 31;18(1):e0270288.\|Stem Cell Rep. 2020 Jan 14;14(1):49-59.\|Adv Sci (Weinh). 2022 Mar 3;e2104682.\|Cell. 2018 Jul 26;174(3):636-648.e18.\|Harvard Medical School LINCS LIBRARY\|J Adv Res. 2023 Oct 6:S2090-1232(23)00299-0.\|Nat Commun. 2020 Jan 3;11(1):88.\|Neurotox Res. 2013 Apr;23(3):238-48.\|Science. 2017 Dec 1;358(6367):eaan4368.
Smiles	O=C(NC1=C2C(NC=C2)=NC=C1)C3=CC=C(C=C3)[C@H](N)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Y-39983 (free base)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	ROCK
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	280.331
Product Description	Y-33075 is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 50 mg/mL (ultrasonic; warming)\|H2O: < 0.1 mg/mL
Manufacturer - Pathway	Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Isoform	ROCK
Clinical information	Phase 2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-10067-10mg-safety-datasheet.pdf