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Cambinol

Cambinol

Item no.	HY-100732-50mg
Manufacturer	MedChem Express
CASRN	14513-15-6
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Skin Cancer Lymphatic System Cancer
Type	Inhibitors
Specific against	other
Purity	99.89
Citations	[1]Heltweg B, et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 2006 Apr 15;66(8):4368-77.\|[2]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330.
Smiles	O=C(C(CC1=C2C=CC=CC2=CC=C1O)=C(C3=CC=CC=C3)N4)NC4=S
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	14513-15-6
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Phospholipase; Sirtuin
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, protect from light)
Molecular Weight	360.43
Product Description	Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 μM and 59 μM, respectively. Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Isoform	SIRT1; SIRT2
Clinical information	No Development Reported

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HY-100732-50mg-safety-datasheet.pdf