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Mivavotinib (monohydrochloride)

Mivavotinib (monohydrochloride)

Item no.	HY-100867A-2mg
Manufacturer	MedChem Express
CASRN	1952251-28-3
Amount	2 mg
Quantity options	100 mg 10 mMx1 mL 10 mg 25 mg 2 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Heart & Blood Cancer Lymphatic System Cancer
Type	Inhibitors
Specific against	other
Purity	99.91
Citations	[1]Lam B, et al. Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK). Bioorg Med Chem Lett. 2016 Dec 15;26(24):5947-5950.\|[2]Purroy N, et al. Inhibition of BCR signaling using the Syk inhibitor TAK-659 prevents stroma-mediated signaling in chronic lymphocytic leukemia cells. Oncotarget. 2017 Jan 3;8(1):742-756.\|[3]Jie Yu, et al. Anti-tumor activity of TAK-659, a dual inhibitor of SYK and FLT-3 kinases, in AML models. Journal of Clinical Oncology 34, no. 15_suppl.\|[4]Cen O, et al. Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of Epstein-Barr Virus-Associated Lymphoma. mSphere. 2018 Aug 22;3(4).
Smiles	FC1=C(N[C@@H]2CCCC[C@@H]2N)N=C(C3=CN(C)N=C3)C4=C1CNC4=O.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	TAK-659 (monohydrochloride),CB-659 (monohydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	FLT3; Syk
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, stored under nitrogen, away from moisture)
Molecular Weight	380.85
Product Description	TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL)[1][2][3][4].
Manufacturer - Research Area	Cancer
Solubility	H2O: 2 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Manufacturer - Pathway	Protein Tyrosine Kinase/RTK
Clinical information	Phase 2

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HY-100867A-2mg-safety-datasheet.pdf