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GGTI298

GGTI298

Item no.	HY-100876-50mg
Manufacturer	MedChem Express
CASRN	180977-44-0
Amount	50 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 25 mg 500 ug 50 mg 5 mg
Category	Food Safety Allergenes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	85.0
Citations	[1]Sheikh IA, et al. The Epac1 signaling pathway regulates Cl- secretion via modulation of apical KCNN4c channels in diarrhea. J Biol Chem. 2013 Jul 12;288(28):20404-15\|[2]Chen S, et al. Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis. Mol Cancer. 2010 Jan 29;9:23.\|[3]McGuire TF, et al. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. J Biol Chem. 1996 Nov 1;271(44):27402-7. Int Immunopharmacol. 2023 Mar 15;117:110014.\|Arthritis Res Ther. 2024 Dec 19;26(1):222.\|J Neuroinflammation. 2024 Nov 14;21(1):295.\|J Oral Biosci. 2023 Aug 23;S1349-0079(23)00122-6.\|Mol Cell Proteomics. 2023 Jun 14;100593.
Smiles	CC(C)C[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=C3C=CC=CC3=CC=C2)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	180977-44-0
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	479.63
Product Description	GGTI298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC50 values of 3 and > 20 μM in vivo, respectively.
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO\|10 mM in H2O
Manufacturer - Pathway	Apoptosis
Clinical information	No Development Reported

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HY-100876-50mg-safety-datasheet.pdf