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Veliparib (dihydrochloride)

Veliparib (dihydrochloride)

Item no.	HY-10130-5mg
Manufacturer	MedChem Express
CASRN	912445-05-7
Amount	5 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 200 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Bladder Cancer Breast Cancer
Type	Inhibitors
Specific against	other
Purity	99.98
Citations	[1]Donawho CK, et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res. 2007 May 1;13(9):2728-37.\|[2]Penning TD, et al. Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. J Med Chem. 2009 Jan 22;52(2):514-23.\|[3]Albert JM, et al. Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin Cancer Res. 2007 May 15;13(10):3033-42.\|[4]Robert J. Kinders, et al. Preclinical Modeling of a Phase 0 Clinical Trial: Qualification of a Pharmacodynamic Assay of Poly (ADP-Ribose) Polymerase in Tumor Biopsies of Mouse Xenografts. Clin Cancer Res. Author manuscript; available in PMC 2009 Nov 1. Electrostatics Joint Conference. 2016 July.\|Harvard Medical School LINCS LIBRARY\|Int J Curr Res Acad Rev. 2017; 5(3): 53-64.\|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.\|Patent. US20200078369A1\|Patent. US20200129476A1\|Acta Pharmacol Sin. 2021 Jul 22.\|Biomed Res Int. 2023 Feb 6.\|BMC Cancer. 2022 Mar 23;22(1):312.\|Cancer Discov. 2017 Sep;7(9):984-998.\|Cancer Genet. 2019 Nov;239:26-32.\|Cancers (Basel). 2024 Nov 5;16(22):3728.\|Cancers (Basel). 2024 Oct 10;16(20):3441.\|Cell Death Dis. 2024 Dec 18;15(12):914.\|Cell Signal. 2025 Mar 2:111709.\|Cells. 2021, 10(3), 599.\|Clin Cancer Res. 2017 Feb 15;23(4):1001-1011. \|Ecotoxicol Environ Saf. 2023 Mar 1;252:114630.\|Front Mol Biosci. 2021 Apr 29;8:633344.\|Front Oncol. 2021 Jul 9;11:681441.\|Int J Biol Macromol. 2023 May 12;124794.\|J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Oct 1;1154:122195.\|J Invest Dermatol. 2024 May 30:S0022-202X(24)00384-1.\|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.\|J Transl Med. 2024 Nov 26;22(1):1062.\|J Vet Med Sci. 2018 Nov 23;80(11):1775-1781. \|Mol Cancer Ther. 2019 Nov;18(11):2063-2073.\|Nanomaterials. 2021, 11(6), 1514.\|Nat Commun. 2021 Jun 24;12(1):3931.\|Neoplasia. 2018 Mar 28;20(5):478-488. \|Neoplasia. 2025 Mar 16:63:101152.\|Neoplasia. 2019 Apr 24;21(6):533-544. \|Oncogene. 2022 Aug 6.\|Oncol Lett. 2025 January 7.\|Patent. US20180263995A1.\|Patent. US20180362972A1.\|Research Square Preprint. 2021 Feb.\|Research Square Preprint. 2024 Feb 21.\|Research Square Preprint. 2024 Nov 06.\|Theranostics. 2020 Jul 25;10(21):9477-9494.
Smiles	O=C(C1=C2NC([C@@]3(NCCC3)C)=NC2=CC=C1)N.Cl.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ABT-888 dihydrochloride
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Autophagy; PARP
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	317.21
Product Description	Veliparib (dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Kis of 5.2 nM and 2.9 nM in cell-free assays, respectively.
Manufacturer - Research Area	Cancer
Solubility	DMSO : ≥ 3.2 mg/mL\|H2O : 250 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy; Cell Cycle/DNA Damage; Epigenetics
Clinical information	Phase 3
Isoform	PARP1; PARP2

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HY-10130-5mg-safety-datasheet.pdf