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Methyl-β-cyclodextrin

Methyl-β-cyclodextrin

Item no.	HY-101461-50g
Manufacturer	MedChem Express
CASRN	128446-36-6
Amount	50 g
Quantity options	10 g 10 mMx1 mL 1 g 25 g 500 mg 50 g 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	[1]Gotoh K, et al. The antitumor effects of methyl-β-cyclodextrin against primary effusion lymphoma via the depletion of cholesterol from lipid rafts. Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):285-9.\|[2]Tiwari G, et al. Cyclodextrins in delivery systems: Applications. J Pharm Bioallied Sci. 2010 Apr;2(2):72-9.\|[3]Mundhara N, et al. Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents. Sci Rep. 2019 May 21;9(1):7638.\|[4]Chen X, et al. Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor. J Biol Chem. 2002 Dec 20;277(51):49631-7.\|[5]Rodal SK, et al. Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles. Mol Biol Cell. 1999;10(4):961-974.\|[6]Yuwei Huang, et al. Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains. Nat Cell Biol. 2019 Aug;21(8):991-1002.
Smiles	CO[C@@H]1[C@H](O[R])[C@H](O[R])[C@@H](C)C(CO[R])O1.[7].[R=H or -CH3]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Methyl-beta-cyclodextrin
Shipping Condition	Room temperature
Available
Manufacturer - Type	Biochemical Assay Reagents
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Biochemical Assay Reagents
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	1310 (Average)
Product Description	Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent[1]. Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis[2]. Methyl-β-cyclodextrin blocks cell migrasome formation[3].
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 100 mg/mL\|H2O: ≥ 50 mg/mL
Manufacturer - Pathway	Others
Clinical information	No Development Reported

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HY-101461-50g-safety-datasheet.pdf