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Temuterkib

Temuterkib

Item no.	HY-101494-5mg
Manufacturer	MedChem Express
CASRN	1951483-29-6
Amount	5 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Skin Cancer Pancreatic Cancer
Type	Inhibitors
Specific against	other
Purity	99.94
Citations	[1]Shripad V. Bhagwat, et al. Abstract 4973: Discovery of LY3214996, a selective and novel ERK1/2 inhibitor with potent antitumor activities in cancer models with MAPK pathway alterations. Cancer Research. July 2017.
Smiles	O=C(C(C=C(C1=NC(NC2=CC=NN2C)=NC=C1)S3)=C3C4(C)C)N4CCN5CCOCC5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LY3214996
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	ERK
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	453.56
Product Description	Temuterkib (LY3214996) is a highly selective inhibitor of ERK1 and ERK2, with IC50 of 5 nM for both enzymes in biochemical assays. Temuterkib potently inhibits cellular p-RSK1 in BRAF and RAS mutant cancer cell lines. Temuterkib shows potent antitumor activities in cancer models with MAPK pathway alterations.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	MAPK/ERK Pathway; Stem Cell/Wnt
Isoform	ERK1; ERK2
Clinical information	Phase 2

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HY-101494-5mg-safety-datasheet.pdf