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Roblitinib

Roblitinib

Item no.	HY-101568-50mg
Manufacturer	MedChem Express
CASRN	1708971-55-4
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 2 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Neural Adhesion Molecules Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Hepatic Cancer Calcium Binding Protein Markers
Type	Inhibitors
Specific against	other
Purity	99.67
Citations	[1]Nicole Buschmann, et al. Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors. WO2015059668A1.\|[2]Robin A Fairhurst, et al. Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4. J Med Chem. 2020 Nov 12;63(21):12542-12573.
Smiles	CN1CC(N(CC2=CC(CCCN3C(NC4=CC(NCCOC)=C(C#N)C=N4)=O)=C3N=C2C=O)CC1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	FGF-401
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	FGFR
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	506.56
Product Description	Roblitinib (FGF-401) is an orally active and highly selective FGFR4 inhibitor with an IC50 of 1.9 nM[1]. Roblitinib has antitumor activity[2].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 5 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Protein Tyrosine Kinase/RTK
Isoform	FGFR1; FGFR2; FGFR3; FGFR4
Clinical information	Phase 2

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HY-101568-50mg-safety-datasheet.pdf