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TRC051384

TRC051384

Item no.	HY-101712-10mM
Manufacturer	MedChem Express
CASRN	867164-40-7
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 200 mg 25 mg 50 mg 5 mg
Category	Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Protein Aggregation, Clearance & Misfolding Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.79
Citations	[1]Mohanan A, et al. Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. Neuropharmacology. 2011 May;60(6):991-9.\|[2]Chen T, et, al. HSP70 attenuates neuronal necroptosis through the HSP90α-RIPK3 pathway following neuronal trauma. Mol Biol Rep. 2023 Sep;50(9):7237-7244.
Smiles	O=C(NC1=CC=C(C(/C=C/C2=NC(N3CCOCC3)=CC=C2)=O)C=C1)NCCN4CCOCC4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	867164-40-7
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	HSP
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	465.54
Product Description	TRC051384 is a potent inducer of heat shock protein 70 (HSP70). TRC051384 exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 can be used for the research of ischemic stroke[1][2].
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: ≥ 100 mg/mL
Manufacturer - Pathway	Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Isoform	HSP70
Clinical information	No Development Reported

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HY-101712-10mM-safety-datasheet.pdf