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(S,R,S)-AHPC (monohydrochloride)

(S,R,S)-AHPC (monohydrochloride)

Item no.	HY-101763A-10mM
Manufacturer	MedChem Express
CASRN	1448189-80-7
Amount	10 mMx1 mL
Quantity options	100 mg 10 mMx1 mL 10 mg 1 g 2 g 2 mg 500 mg 50 mg 5 g 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.83
Citations	[1]Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.ACS Chem Biol. 2015 Aug 21;10(8):1831-7.\|[2]Vu LP, et al. Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers[J]. J Med Chem. 2023 Sep 28;66(18):12776-12811. \|[3]Krieger J, et al. Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design. ChemMedChem. 2023 Apr 17;18(8):e202200615.
Smiles	O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	VH032-NH2 (monohydrochloride),VHL ligand 1 (monohydrochloride)
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Ligands for E3 Ligase
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, stored under nitrogen)
Molecular Weight	467.02
Product Description	(S, R, S)-AHPC (VH032-NH2; VHL ligand 1) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 125 mg/mL (ultrasonic)\|H2O: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	PROTAC
Isoform	von Hippel-Lindau (VHL)
Clinical information	No Development Reported

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HY-101763A-10mM-safety-datasheet.pdf