Comparison

STAT5-IN-1

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 50mg
Item no. HY-101853-50mg
eClass 6.1 30220300
eClass 9.0 32160605
Available
CAS
285986-31-4
MWt
293.28
Formula
C16H11N3O3
Solubility
DMSO : 20 mg/mL (68.19 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble)
Clinical Information
No Development Reported
Research Area
Cancer
Pathway
JAK/STAT Signaling, Stem Cell/Wnt
Target
STAT, STAT
SMILES
O=C(C1=CC=CN=C1)N/N=C/C2=COC3=CC=CC=C3C2=O
Biological Activity
STAT5-IN-1 is a STAT5 inhibitor with an IC50 of 47 uM for STAT5beta isoform.
IC50 & Target: IC50: 47 uM (STAT5beta)[1]
In Vitro: The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 uM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5beta, but leads to complete loss of selectivity against other STAT family members[1].

Note: The presented information and documents (Manual, Product Datasheet and Safety Datasheet) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

Amount: 50mg
Available: In stock
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