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Numidargistat

Numidargistat

Item no.	HY-101979-10mg
Manufacturer	MedChem Express
CASRN	2095732-06-0
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Hepatic Cancer
Type	Inhibitors
Specific against	other
Purity	98.0
Citations	[1]Steggerda SM, et al. Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. J Immunother Cancer. 2017 Dec 19;5(1):101. Biomed Pharmacother. 2022 Jun 24;153:113321.\|Research Square Preprint. 2022 Mar.\|The University of Chicago. 2023 Dec.\|bioRxiv. 2023 Sep 10.\|Cancer Cell . 2025 Feb 10;43(2):269-291.e19. \|Cancer Lett. 2023 May 5;216208.\|Cell Commun Signal. 2023 Sep 18;21(1):236.\|J Physiol. 2020 Nov;598(21):4907-4925.\|Patent. US20240307497A1.
Smiles	O=C([C@@H](N)C)N1C[C@H](CCCB(O)O)[C@](N)(C(O)=O)C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CB-1158,INCB01158
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Arginase
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	287.12
Product Description	Numidargistat (CB-1158) is a potent and orally active inhibitor of arginase, with IC50s of 86 nM and 296 nM for recombinant human arginase 1 and recombinant human arginase 2, respectively. Immuno-oncology agent[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Immunology/Inflammation; Metabolic Enzyme/Protease
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-101979-10mg-safety-datasheet.pdf