FM-381

Item no.	HY-102046-100mg
Manufacturer	MedChem Express
CASRN	2226521-65-7
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 2 mg 50 mg 5 mg
Category	Neuroscience Neural Lineage Markers Neural Transcription Factors Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.58
Formula	C24H24N6O2
Citations	[1]Forster M, et al. Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket. Cell Chem Biol. 2016 Nov 17;23(11):1335-1340.
Smiles	CN(C(/C(C#N)=C/C1=CC=C(C2=NC3=CN=C(NC=C4)C4=C3N2C5CCCCC5)O1)=O)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2226521-65-7
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	JAK
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	428.49
Product Description	FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO : 8.33 mg/mL (ultrasonic)
Manufacturer - Pathway	Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Isoform	JAK3
Clinical information	No Development Reported

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HY-102046-100mg-safety-datasheet.pdf