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Midostaurin

Midostaurin

Manufacturer	MedChem Express
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Colorectal Cancer
Type	Inhibitors
Specific against	other
Amount	5 mg
Item no.	HY-10230-5mg
Targets	KIT
CASRN	120685-11-2
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	Midostaurin (PKC412; CGP 41251) is an orally active, reversible multi-targeted protein kinase inhibitor. Midostaurin inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1][2]. Midostaurin also upregulates endothelial nitric oxide synthase (eNOS) gene expression. Midostaurin shows powerful anticancer effects[3].
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	570.64
Clinical_Information	Launched
Manufacturers Research_Area	Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic)
Isoform	eNOS; PKCα; PKCβ; PKCγ; PKCδ; PKCε; PKCζ; PKCη
Pathway	Apoptosis; Epigenetics; Immunology/Inflammation; Protein Tyrosine Kinase/RTK; TGF-beta/Smad
Manufacturers Product type	Reference compound

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HY-10230-5mg-safety-datasheet.pdf