PX-478

Item no.	HY-10231-10mg
Manufacturer	MedChem Express
CASRN	685898-44-6
Amount	10 mg
Quantity options	100 mg 10 mMx1 mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.0
Citations	[1]Palayoor ST, et al. PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells. Int J Cancer. 2008 Nov 15;123(10):2430-2437.\|[2]Agarwal S, et al. Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification. Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):E338-47.
Smiles	[O-][N+](CCCl)(CCCl)C(C=C1)=CC=C1C[C@H](N)C(O)=O.Cl.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	685898-44-6
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Autophagy; HIF/HIF Prolyl-Hydroxylase
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, stored under nitrogen, away from moisture)
Molecular Weight	394.12
Product Description	PX-478 is an orally active HIF-1α inhibitor with potent antitumor activities. PX-478 can cross the blood-brain barrier[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: ≥ 35 mg/mL
Manufacturer - Pathway	Autophagy; Metabolic Enzyme/Protease
Clinical information	Phase 1

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HY-10231-10mg-safety-datasheet.pdf