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PD 123319 (ditrifluoroacetate)

PD 123319 (ditrifluoroacetate)

Item no.	HY-10259A-5mg
Manufacturer	MedChem Express
CASRN	136676-91-0
Amount	5 mg
Quantity options	10 mM/1 mL 10 mg 50 mg 5 mg
Category	Cardiovascular Research Hypertension Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.82
Citations	[1]Blankley CJ, et al. Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. J Med Chem. 1991 Nov;34(11):3248-60.\|[2]Boulay G, et al. Modulation of angiotensin II binding affinity by allosteric interaction of polyvinyl sulfate with an intracellular domain of the DuP-753-sensitive angiotensin II receptor of bovine adrenal glomerulosa. Mol Pharmacol. 1992 Apr;41(4):809-15\|[3]Estrup TM, et al. No effect of angiotensin II AT(2)-receptor antagonist PD 123319 on cerebral blood flow autoregulation. J Renin Angiotensin Aldosterone Syst. 2001 Sep;2(3):188-92.\|[4]Brillante DG, et al. Effects of intravenous PD 123319 on haemodynamic and arterial stiffness indices in healthy volunteers. J Renin Angiotensin Aldosterone Syst. 2005 Sep;6(2):102-6. FASEB J. 2018 Sep;32(9):5051-5062.\|Acta Pharmacol Sin. 2024 Mar 15.\|FASEB J. 2019 May;33(5):6254-6268. \|Int Immunopharmacol. 2022 Jun 17;110:108921.\|J Exp Med. 2022 Mar 7;219(3):e20211001.\|Redox Biol. October 2021, 102115.\|Rep Biochem Mol Biol. 2021 Aug.\|Rep Biochem Mol Biol. 2021 Jul;10(2):314-326.\|SSRN. 13 Apr 2022.
Smiles	FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.O=C([C@@H]1CC2=C(N=CN2CC3=CC=C(N(C)C)C(C)=C3)CN1C(C(C4=CC=CC=C4)C5=CC=CC=C5)=O)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	136676-91-0
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Angiotensin Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	736.66
Product Description	PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.
Manufacturer - Research Area	Cardiovascular Disease; Endocrinology
Solubility	H2O: ≥ 36 mg/mL
Manufacturer - Pathway	GPCR/G Protein
Isoform	AT2 Receptor
Clinical information	No Development Reported

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HY-10259A-5mg-safety-datasheet.pdf