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Enzastaurin

Enzastaurin

Item no.	HY-10342-5mg
Manufacturer	MedChem Express
CASRN	170364-57-5
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 200 mg 50 mg 5 mg
Category	Oncology Neuroscience Aging & Neurological Disorders Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer Head & Neck Cancer Gastric Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.92
Formula	C32H29N5O2
Citations	[1]Rovedo MA, et al. Inhibition of glycogen synthase kinase-3 increases the cytotoxicity of enzastaurin. J Invest Dermatol, 2011, 131(7), 1442-1449. [2]Podar K, et al. Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl). Blood, 2007, 109(4), 1669-1677. [3]Graff JR, et al. The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res, 2005, 65(16),
Smiles	O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3C4=CN(C5CCN(CC6=NC=CC=C6)CC5)C7=C4C=CC=C7)NC3=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LY317615
Available
Product Description	Enzastaurin (LY317615) is a potent and selective PKCβ inhibitor with an IC50 of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	515.61
Clinical Information	Launched
Manufacturers Research Area	Cancer
Solubility	DMSO : 8.33 mg/mL (ultrasonic)
Target	Apoptosis; Autophagy; PKC
Manufacturers Target	Apoptosis; Autophagy; PKC
Isoform	PKCα; PKCβ; PKCγ; PKCε
Manufacturers Pathway	Apoptosis; Autophagy; Epigenetics; TGF-beta/Smad
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-10342-5mg-safety-datasheet.pdf