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Thalidomide-4-OH

Thalidomide-4-OH

Item no.	HY-103596-1g
Manufacturer	MedChem Express
CASRN	5054-59-1
Amount	1 g
Quantity options	100 mg 10 g 10 mMx1 mL 1 g 2 g 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.92
Citations	[1]Marks MG, et al. Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol Pharm Bull. 2002 May;25(5):597-604.
Smiles	OC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Cereblon ligand 2,E3 ligase Ligand 2
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Autophagy; Ligands for E3 Ligase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, stored under nitrogen)
Molecular Weight	274.23
Product Description	Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Autophagy; PROTAC
Isoform	Cereblon
Clinical information	No Development Reported

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HY-103596-1g-safety-datasheet.pdf