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Canertinib

Canertinib

Item no.	HY-10367-10mM
Manufacturer	MedChem Express
CASRN	267243-28-7
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 200 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.74
Citations	[1]Smaill JB, et al. Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions. J Med Chem. 2000 Apr 6;43(7):1380-97.\|[2]Djerf Severinsson EA, et al. The pan-ErbB receptor tyrosine kinase inhibitor canertinib promotes apoptosis of malignant melanoma in vitro and displays anti-tumor activity in vivo. Biochem Biophys Res Commun. 2011 Oct 28;414(3):563-8.\|[3]McAndrews KM, et, al. Mechanisms associated with biogenesis of exosomes in cancer. Mol Cancer. 2019 Mar 30;18(1):52.\|[4]Smee DF, et, al. Progress in the discovery of compounds inhibiting orthopoxviruses in animal models. Antivir Chem Chemother. 2008;19(3):115-24. Biochemistry. 2017 Jun 13;56(23):2921-2927.\|Biochemistry. 2018 Feb 27;57(8):1369-1379.\|bioRxiv. 2023 Oct 6.\|J Biol Chem. 2012 Mar 23;287(13):9742-52.\|J Med Chem. 2019 May 9;62(9):4772-4778.\|Oncotarget. 2020 Nov 3;11(44):3921-3932.\|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.\|Harvard Medical School LINCS LIBRARY\|J Cell Sci. 2015 Sep 1;128(17):3317-29.
Smiles	O=C(NC1=C(C=C2C(C(NC3=CC=C(C(Cl)=C3)F)=NC=N2)=C1)OCCCN4CCOCC4)C=C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CI-1033,PD-183805
Similar products	267243-28-7
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	EGFR; Orthopoxvirus
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	485.94
Product Description	Canertinib (CI-1033; PD-183805) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. Canertinib is active against vaccinia virus respiratory infection in mice[1][2][3][4].
Manufacturer - Research Area	Cancer; Infection
Solubility	DMSO: 4.9 mg/mL (warming)\|Ethanol: 12.5 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Isoform	EGFR/ErbB1/HER1; ErbB2/HER2
Clinical information	Phase 2

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HY-10367-10mM-safety-datasheet.pdf