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Samuraciclib (hydrochloride)

Samuraciclib (hydrochloride)

Item no.	HY-103712A-25mg
Manufacturer	MedChem Express
CASRN	1805789-54-1
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.98
Citations	[1]Hazel P, et al. Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. ChemMedChem. 2017 Mar 7;12(5):372-380.\|[2]Patel H, et al. ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment. Mol Cancer Ther. 2018 Jun;17(6):1156-1166. Adv Sci (Weinh). 2024 Dec 10:e2413103.\|Biochem Biophys Res Commun. 2024 Aug 28:735:150608.\|Cell Death Dis. 2019 Aug 9;10(8):602.\|Clin Cancer Res. 2024 Feb 21.\|Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12986-12995. \|Res Sq. 2024 Jul 29.\|Structure. 2024 Jun 9:S0969-2126(24)00188-6.\|Int J Mol Sci. 2022 Feb 24;23(5):2493.\|J Cancer Res Clin Oncol. 2022 Nov 18.
Smiles	O[C@H]1CNCC[C@@H]1CNC2=NC3=C(C(C)C)C=NN3C(NCC4=CC=CC=C4)=C2.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CT7001 (hydrochloride),ICEC0942 (hydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; CDK
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, stored under nitrogen, away from moisture)
Molecular Weight	430.97
Product Description	Samuraciclib hydrochloride (CT7001 hydrochloride) is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC50 of 41 nM. Samuraciclib hydrochloride displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2 (IC50 of 578 nM), CDK5 and CDK9, respectively. Samuraciclib hydrochloride inhibits the growth of breast cancer cell lines with GI50 values between 0.2-0.3 µM. Samuraciclib hydrochloride has anti-tumor effects[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: 55 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Cell Cycle/DNA Damage
Isoform	CDK1; CDK2; CDK4; CDK5; CDK6; CDK7; CDK9
Clinical information	Phase 2

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HY-103712A-25mg-safety-datasheet.pdf