QC6352

Manufacturer	MedChem Express
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer
Type	Inhibitors
Specific against	other
Amount	25 mg
Item no.	HY-104048-25mg
Targets	Histone Demethylase
CASRN	1851373-36-8
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	QC6352 is an orally active KDM4 inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits KDM4 different isoforms with IC50s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against KDM5 with an IC50 of 750 nM (KDM5B)[1][2].
StorageTemperature	4°C (Powder, protect from light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	387.47
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 16.67 mg/mL (ultrasonic)
Manufacturers Target	Histone Demethylase
Isoform	KDM4; KDM5
Pathway	Epigenetics
Manufacturers Product type	Reference compound

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HY-104048-25mg-safety-datasheet.pdf