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SB-431542

SB-431542

Manufacturer	MedChem Express
Category	Oncology Food Safety Drugs Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Cardiovascular Research Thrombosis & Hemostasis Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Colorectal Cancer Neurodegeneration Markers;Research Area Oncology By Organ Breast Cancer
Type	Inhibitors
Specific against	other
Clone	N/A
Amount	50 mg
Item no.	HY-10431-50mg
Targets	TGF-β Receptor
CASRN	301836-41-9
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	384.39
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL\|Ethanol : 11.17 mg/mL (ultrasonic; warming)
Manufacturers Target	Apoptosis; Organoid; TGF-β Receptor
Isoform	ALK4; ALK5; ALK7
Pathway	Apoptosis; Stem Cell/Wnt; TGF-beta/Smad
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-10431-50mg-safety-datasheet.pdf