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Zoniporide (hydrochloride hydrate)

Zoniporide (hydrochloride hydrate)

Item no.	HY-105064D-1mg
Manufacturer	MedChem Express
CASRN	863406-85-3
Amount	1 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.37
Citations	[1]Tracey WR, et al. Zoniporide: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1). Cardiovasc Drug Rev. 2003 Spring;21(1):17-32.\|[2]Guzman-Perez A, et al. Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility. Bioorg Med Chem Lett. 2001 Mar 26;11(6):803-7. J Biol Chem. 2021 Sep 3;101166.\|Carbohydr Polym. 1 January 2023, 120179.
Smiles	O=C(C1=C(C2CC2)N(C3=C4C=CC=NC4=CC=C3)N=C1)NC(N)=N.[H]Cl.[H]O[H]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CP-597396 (hydrochloride hydrate)
Similar products	CP-597396 (hydrochloride hydrate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Na+/H+ Exchanger (NHE)
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	374.82
Product Description	Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM)[1][2].
Manufacturer - Research Area	Cardiovascular Disease
Solubility	DMSO: 20 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O: ≥ 100 mg/mL
Manufacturer - Pathway	Membrane Transporter/Ion Channel
Clinical information	No Development Reported

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HY-105064D-1mg-safety-datasheet.pdf