GW3965

Item no.	HY-10627-50mg
Manufacturer	MedChem Express
CASRN	405911-09-3
Amount	50 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Neuroscience Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Targets for Rodent Neurosciences Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	[1]Mitro, Nico., et al. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International (2012), 60(6), 616-621.\|[2]Guo, Deliang., et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery (2011), 1(5), 442-456.\|[3]Spyridon, Michael., et al. LXR as a novel antithrombotic target. Blood (2011), 117(21), 5751-5761. Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1136-E1145. \|Bioconjug Chem. 2015 Nov 18;26(11):2216-22. \|Biogerontology. 2025 Jan 31;26(2):49.\|Cancer Lett. 2023 May 5;216208.\|Cell Death Differ. 2020 Aug;27(8):2433-2450. \|J Am Heart Assoc. 2021 May 8;e018455.\|J Ethnopharmacol. 2023 May 24;315:116684.\|Sci Adv. 15 Jul 2022.\|Theranostics. 2020 Jul 11;10(19):8834-8850. \|Vet Microbiol. 2024 Jan, 288, 109948.\|bioRxiv. 2023 Mar 10.\|Environ Int. 2024 Nov 26:194:109168.\|Radboud University Nijmegen. 2021 Mar.\|Viruses. 2022, 14(3), 514.
Smiles	ClC1=C(C(F)(F)F)C=CC=C1CN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CCCOC4=CC(CC(O)=O)=CC=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	405911-09-3
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	LXR
Shipping Temperature	Room temperature
Molecular Weight	582.05
Product Description	GW3965 is a potent, selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively[1][2][3].
Manufacturer - Research Area	Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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