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PTP1B-IN-1

PTP1B-IN-1

Item no.	HY-10704-10mg
Manufacturer	MedChem Express
CASRN	612530-44-6
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Molecular Targets for Neuroscience By Cell Type Carcinoma Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.65
Citations	[1]Black E, et al. Structure-based design of protein tyrosine phosphatase-1B inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2503-7.\|[2]Vintonyak VV, et al. Using small molecules to target protein phosphatases. Bioorg Med Chem. 2011 Apr 1;19(7):2145-55.\|[3]Jiao B, et al., Protein tyrosine phosphatase 1B contributes to neuropathic pain by aggravating NF-κB and glial cells activation-mediated neuroinflammation via promoting endoplasmic reticulum stress. CNS Neurosci Ther. 2024 Feb;30(2):e14609.
Smiles	O=S(N1C2=CC=CC=C2)(NC(C1)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PTP1B inhibitor
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	NF-κB; Phosphatase
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	212.23
Product Description	PTP1B-IN-1 (Compound 7a) is a small molecule inhibitor of PTP1B with an IC50 value of 1.6 mM. It is often used as the mother core for derivatives of analogues[1][2].
Manufacturer - Research Area	Inflammation/Immunology; Neurological Disease
Solubility	DMSO: ≥ 38 mg/mL
Manufacturer - Pathway	Metabolic Enzyme/Protease; NF-κB
Clinical information	No Development Reported

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HY-10704-10mg-safety-datasheet.pdf