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Thalidomide-O-amido-C4-NH2

Thalidomide-O-amido-C4-NH2

Item no.	HY-107438-500mg
Manufacturer	MedChem Express
CASRN	1799711-24-2
Amount	500 mg
Quantity options	100 mg 1 ea 1 g 2 g 500 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Testicular & Prostate Cancer
Type	Inhibitors
Specific against	other
Citations	[1]Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression.J Med Chem. 2018 Jan 25;61(2):462-481. [2]James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.
Smiles	NCCCCNC(COC1=C(C(N2C(CCC3=O)C(N3)=O)=O)C(C2=O)=CC=C1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Cereblon Ligand-Linker Conjugates 6,E3 Ligase Ligand-Linker Conjugates 19
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Shipping Temperature	Room temperature
Molecular Weight	402.40
Product Description	Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1].
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Apoptosis; Autophagy; PROTAC
Isoform	Cereblon
Clinical information	No Development Reported

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