PI-828

Item no.	HY-108606-1mg
Manufacturer	MedChem Express
CASRN	942289-87-4
Amount	1 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Cardiovascular Research Thrombosis & Hemostasis Heart Failure Myocardial Infarction Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.62
Citations	[1]Gharbi SI, et al. Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J. 2007 May 15;404(1):15-21.\|[2]Zellefrow CD, et al. Identification of druggable targets for radiation mitigation using a small interfering RNA screening assay. Radiat Res. 2012 Sep;178(3):150-9.\|[3]Kulkarni AA, et al. Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy. Cancer Res. 2013 Dec 1;73(23):6987-97.
Smiles	O=C1C=C(N2CCOCC2)OC3=C(C4=CC=C(N)C=C4)C=CC=C13
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	942289-87-4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Casein Kinase; PI3K
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	322.36
Product Description	PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 12.5 mg/mL
Manufacturer - Pathway	Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt
Isoform	CK2; PI3Kα
Clinical information	No Development Reported

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HY-108606-1mg-safety-datasheet.pdf