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PMX 205

PMX 205

Item no.	HY-110136-500ug
Manufacturer	MedChem Express
CASRN	514814-49-4
Amount	500 ug
Quantity options	100 mg 10 mg 1 ea 1 mg 500 ug 5 mg
Category	Neuroscience Neural Lineage Markers Neuroinflammation Molecular Targets for Neuroscience Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.54
Citations	[1]Kosni NN, et al. Expression of complement C5a receptor and the viability of 4T1 tumor cells following agonist-antagonist treatment. J Cancer Res Ther. 2016 Apr-Jun;12(2):590-6.\|[2]Woodruff TM, et al. The complement factor C5a contributes to pathology in a rat model of amyotrophic lateral sclerosis. J Immunol. 2008 Dec 15;181(12):8727-34.\|[3]Fonseca MI, et al. Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J Immunol. 2009 Jul 15;183(2):1375-83. Cell Mol Neurobiol. 2022 Aug 25.\|Cell Rep. 2023 Mar 15;42(3):112240.\|Theranostics. 2019 Oct 12;9(25):7566-7582. \|Adv Sci (Weinh). 2024 Jun 5:e2400819.\|Cell Death Dis. 2024 Oct 5;15(10):729.\|Clin Immunol. 2025 Feb 19:110459.\|Int J Cancer. 2023 Jul 1;153(1):224-237.\|La Trobe University. 2022 Jan.
Smiles	O=C([C@H](NC([C@@]1([H])N(CCC1)C([C@](NC(CCC2=CC=CC=C2)=O)([H])CCCNC([C@H](CCCNC(N)=N)NC3=O)=O)=O)=O)CC4CCCCC4)N[C@@]3([H])CC5=CNC6=CC=CC=C56
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	514814-49-4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Complement System
Shipping Temperature	Room temperature
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Molecular Weight	839.04
Product Description	PMX 205 is a potent complement C5a receptor (C5aR; CD88) antagonist.
Manufacturer - Research Area	Inflammation/Immunology
Solubility	10 mM in DMSO
Manufacturer - Pathway	Immunology/Inflammation
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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