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Alendronate (sodium hydrate)

Alendronate (sodium hydrate)

Item no.	HY-11101-10mM
Manufacturer	MedChem Express
CASRN	121268-17-5
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 500 mg
Category	Metabolism Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.6
Citations	[1]Fisher JE, et al. Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):133-8\|[2]Bergstrom JD, et al. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys. 2000 Jan 1;373(1):231-41.\|[3]Keller RK, et al. Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway. Biochem Biophys Res Commun. 1999 Dec 20;266(2):560-3.\|[4]Elliott SN, et al. Alendronate induces gastric injury and delays ulcer healing in rodents. Life Sci. 1998;62(1):77-91.\|[5]Stearns ME, et al. Effects of alendronate and taxol on PC-3 ML cell bone metastases in SCID mice. Invasion Metastasis. 1996;16(3):116-31. Am J Physiol Endocrinol Metab. 2024 May 8.\|Bone. 2024 Nov 29:192:117348.\|Int J Mol Sci. 2024 Jul 16;25(14):7798.\|J Biol Chem. 2019 Jul 19;294(29):11240-11247.\|J Med Chem. 2024 Aug 26.\|Cell Rep. 2022 Oct 25;41(4):111508.
Smiles	OP(C(O)(CCCN)P(O)(O[Na])=O)(O)=O.[3H2O]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Alendronate,MK 217,G-704650 Adronat
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Others
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	325.12
Product Description	Alendronate (sodium hydrate) is a farnesyl diphosphate synthase inhibitor with IC50 of 460 nM.
Manufacturer - Research Area	Cancer
Solubility	H2O: ≥ 28.57 mg/mL
Manufacturer - Pathway	Others
Clinical information	Launched

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HY-11101-10mM-safety-datasheet.pdf