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RO4929097

RO4929097

Item no.	HY-11102-10mg
Manufacturer	MedChem Express
CASRN	847925-91-1
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Skin Cancer Breast Cancer
Type	Inhibitors
Specific against	other
Purity	99.01
Citations	[1]Luistro L, et al. Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties. Cancer Res. 2009, 69(19), 7672-7680.\|[2]Debeb BG, et al. Pre-clinical studies of Notch signaling inhibitor RO4929097 in inflammatory breast cancer cells. Breast Cancer Res Treat. 2012.\|[3]Huynh C, et al. The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma. PLoS One. 2011, 6(9), e25264.
Smiles	O=C(C(C)(C(NCC(F)(C(F)(F)F)F)=O)C)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	RG-4733
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Notch; γ-secretase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, stored under nitrogen)
Molecular Weight	469.40
Product Description	RO4929097 (RG-4733) is an orally active γ secretase inhibitor with an IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively[1].
Manufacturer - Research Area	Neurological Disease; Cancer
Solubility	DMSO: ≥ 49 mg/mL
Manufacturer - Pathway	Neuronal Signaling; Stem Cell/Wnt
Clinical information	Phase 2

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HY-11102-10mg-safety-datasheet.pdf