« Back
Home /
PDGFRα kinase inhibitor 1

PDGFRα kinase inhibitor 1

Item no.	HY-111507-10mM
Manufacturer	MedChem Express
CASRN	2209053-93-8
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.51
Citations	[1]Wang Q, et al. Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibitor for PDGFRα driving chronic eosinophilic leukemia. Eur J Med Chem. 2018 Apr 25;150:366-384.
Smiles	CC(C=CC(NC(C1=CC=C(CN(CCN(C)C)C(C2=CC=CN=C2)=O)C=C1)=O)=C3)=C3NC4=NC=CC(C5=CC=CN=C5)=N4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2209053-93-8
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	PDGFR
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	586.69
Product Description	PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 260 mg/mL (ultrasonic)
Manufacturer - Pathway	Protein Tyrosine Kinase/RTK
Isoform	PDGFRα; PDGFRβ
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-111507-10mM-safety-datasheet.pdf