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AMG 333

AMG 333

Item no.	HY-112703-1mg
Manufacturer	MedChem Express
CASRN	1416799-28-4
Amount	1 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.82
Citations	[1]Horne DB, et al. Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine. J Med Chem. 2018 Sep 27;61(18):8186-8201.
Smiles	FC1=CC=CN=C1[C@H](C2=CC(F)=C(OC(F)(F)F)C=C2)NC(C3=NC=C(C(O)=O)C=C3)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1416799-28-4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	TRP Channel
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	453.32
Product Description	AMG 333 is an orally active and highly selective TRPM8 antagonist with an IC50 of 13 nM.
Manufacturer - Research Area	Neurological Disease; Cardiovascular Disease
Solubility	DMSO : ≥ 125 mg/mL
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	Phase 1

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HY-112703-1mg-safety-datasheet.pdf