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3-Aminobenzamide

3-Aminobenzamide

Item no.	HY-12022-500mg
Manufacturer	MedChem Express
CASRN	3544-24-9
Amount	500 mg
Quantity options	10 mM/1 mL 1 g 200 mg 500 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.99
Citations	[1]Brock WA, et al. Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase. Cancer Lett. 2004 Mar 18;205(2):155-60.\|[2]Radovits T, et al. Poly(ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by reactive oxidant hydrogen peroxide in vitro. Eur J Pharmacol. 2007 Jun 14;564(1-3):158-66.\|[3]Szabo C, et al. Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice. Diabetes. 2006 Nov;55(11):3004-12.\|[4]Clark RS, et al. Local administration of the poly(ADP-ribose) polymerase inhibitor INO-1001 prevents NAD+ depletion and improves water maze performance after traumatic brain injury in mice. J Neurotrauma. 2007 Aug;24(8):1399-405.
Smiles	O=C(C1=CC=CC(N)=C1)N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PARP-IN-1
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	PARP
Shipping Temperature	Room Temperature
Storage Conditions	Store at room temperature 3 years
Molecular Weight	136.15
Product Description	3-Aminobenzamide (PARP-IN-1) is a potent inhibitor of PARP with IC50 of appr 50 nM in CHO cells, and acts as a mediator of oxidant-induced myocyte dysfunction during reperfusion.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: ≥ 11.11 mg/mL
Manufacturer - Pathway	Cell Cycle/DNA Damage; Epigenetics
Isoform	PARP
Clinical information	No Development Reported

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HY-12022-500mg-safety-datasheet.pdf