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Chelerythrine (chloride)

Chelerythrine (chloride)

Item no.	HY-12048-10mg
Manufacturer	MedChem Express
CASRN	3895-92-9
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Metabolism Diabetes Glucose Homeostasis Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Bladder Cancer Breast Cancer
Type	Inhibitors
Specific against	other
Purity	99.11
Citations	[1]Li W, et al. Effect of Chelerythrine Against Endotoxic Shock in Mice and Its Modulation of Inflammatory Mediators in Peritoneal Macrophages Through the Modulation of Mitogen-Activated Protein Kinase (MAPK) Pathway. Inflammation. 2012 Jul 24.\|[2]Pencikova K, et al. Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line. Phytomedicine. 2012 Jul 15;19(10):890-5. Epub 2012 May 14.\|[3]Chen XM, et al. Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines. Oncol Lett. 2016 Jun;11(6):3917-3924\|[4]Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9.\|[5]Chan SL, et al.Identification of chelerythrine as an inhibitor of BclXL function.J Biol Chem. 2003 Jun 6;278(23):20453-6.\|[6]Tang ZH, et al.Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells.Redox Biol. 2017 Aug;12:367-376. Cytokine. 2024 Jul 26:182:156717.\|Harvard Medical School LINCS LIBRARY\|Heliyon. 2024 Jul 28;10(15):e35368.\|J Headache Pain. 2022 Mar 8;23(1):35.\|J Inflamm Res. 2025 Mar 20:18:4213-4231.\|Phytother Res. 2023 Jul 4.\|Research Square Preprint. 2020 Oct.\|Sci Rep. 2017 Aug 23;7(1):9201.\|Biochem Biophys Res Commun. 2024 Oct 29:739:150914.\|Cancer Cell Int. 2023 Jun 17;23(1):117.\|Cell Commun Signal. 2021 Oct 11;19(1):103.\|FASEB J. 2019 Dec;33(12):13644-13659.\|Fishes. 2022, 7(5), 229.\|Front Pharmacol. 13 May 2021.\|Front Physiol. 2021 Oct 28;12:770430.\|Planta Med. 2024 Jun;90(7-08):523-533.
Smiles	C[N+]1=CC2=C(C(OC)=CC=C2C3=C1C4=CC5=C(OCO5)C=C4C=C3)OC.[Cl-]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	3895-92-9
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis; Autophagy; Bcl-2 Family; PKC
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	383.82
Product Description	Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.
Manufacturer - Research Area	Cancer; Metabolic Disease; Inflammation/Immunology
Solubility	DMSO: 4.35 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Autophagy; Epigenetics; TGF-beta/Smad
Isoform	PKC
Clinical information	No Development Reported

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HY-12048-10mg-safety-datasheet.pdf