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ON 146040

ON 146040

Item no.	HY-12338-100mg
Manufacturer	MedChem Express
CASRN	1404231-34-0
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	95.05
Citations	[1]Targeting oncogenic STAT3 and STAT5 signaling with on 146040, a small molecule inhibitor of PI3K α/δ and BCR-ABL.
Smiles	CN(CC1)CCN1C(C=C2)=CC=C2NC3=NC(S/C(C(N4)=O)=C\C5=CC=C([N+]([O-])=O)C=C5)=C4C=N3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1404231-34-0
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Bcr-Abl; PI3K
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	489.55
Product Description	ON 146040 is a potent PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibits Abl1 (IC50<150 nM).
Manufacturer - Research Area	Cancer
Solubility	DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Isoform	PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Clinical information	No Development Reported

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HY-12338-100mg-safety-datasheet.pdf