FH1

Item no.	HY-12346-10mM
Manufacturer	MedChem Express
CASRN	03.05.2719
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.17
Citations	[1]Shan J, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol. 2013 Aug;9(8):514-20.\|[2]Lunzhi Yuan, et al. A Chimeric Humanized Mouse Model by Engrafting the Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cell for the Chronic Hepatitis B Virus Infection. Front Microbiol. 2018 May 8;9:908.\|[3]Schepers AG, et al. Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function. ACS Chem Biol. 2021 Sep 17;16(9):1770-1778.
Smiles	CC(NC1=CC=C(CC2=CC=C(NC(C)=O)C=C2)C=C1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	NSC 12407,BRD-K4477
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Targets	Quinone Reductase
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	282.34
Product Description	FH1 (NSC 12407) is a NQO2 inhibitor with hepatoprotective effects. FH1 enhances hepatocyte function and promotes differentiation of induced pluripotent stem (iPS)-derived hepatocytes to a more mature phenotype and maturation of well-differentiated hepatocyte-like cell (iHeps) cultures. FH1 protects against Acetaminophen (HY-66005)-induced hepatotoxicity in both embryos and adult zebrafish[1][2][3].
Manufacturer - Research Area	Others
Solubility	DMSO: 13 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Metabolic Enzyme/Protease
Clinical information	Phase 1

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HY-12346-10mM-safety-datasheet.pdf