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NMS-P715

NMS-P715

Item no.	HY-12382-100mg
Manufacturer	MedChem Express
CASRN	1202055-32-0
Amount	100 mg
Quantity options	100 mg 10 mg 1 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.30
Citations	[1]Colombo R, et al. Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. Cancer Res. 2010 Dec 15;70(24):10255-64.\|[2]Slee RB, et al. Selective inhibition of pancreatic ductal adenocarcinoma cell growth by the mitotic MPS1 kinase inhibitor NMS-P715. Mol Cancer Ther. 2014 Feb;13(2):307-315.
Smiles	O=C(C1=NN(C)C2=C1CCC3=C2N=C(NC4=CC=C(C(NC5CCN(CC5)C)=O)C=C4OC(F)(F)F)N=C3)NC6=C(CC)C=CC=C6CC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1202055-32-0
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Mps1
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	676.73
Product Description	NMS-P715 is a selective, ATP-competitive inhibitor of MPS1, with an IC50 of 182 nM.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 2 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Cytoskeleton
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-12382-100mg-safety-datasheet.pdf