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Talfirastide

Talfirastide

Manufacturer	MedChem Express
Category	Oncology Food Safety Hormones Neuroscience Aging & Neurological Disorders Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Colorectal Cancer
Type	Inhibitors
Specific against	other
Clone	N/A
Amount	25 mg
Item no.	HY-12403-25mg
Targets	ACE
CASRN	51833-78-4
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity [1][2][3].
StorageTemperature	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	899.00
Clinical_Information	Phase 3
Manufacturers Research_Area	Inflammation/Immunology; Cardiovascular Disease; Endocrinology
Solubility	H2O : ≥ 30.2 mg/mL
Isoform	AT1 Receptor
Pathway	GPCR/G Protein; Metabolic Enzyme/Protease
Manufacturers Product type	Peptides

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HY-12403-25mg-safety-datasheet.pdf