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INT-767

INT-767

Item no.	HY-12434-10mg
Manufacturer	MedChem Express
CASRN	1000403-03-1
Amount	10 mg
Quantity options	10mM/1mL 10 mg 1 mg 50 mg 5 mg
Category	Metabolism Diabetes Cholesterol & Lipid Metabolism Inhibitors & Compound Libraries Small Molecules Other Lipid\Cholesterol Metabolism Modulators
Type	Inhibitors
Specific against	other
Purity	99.81
Formula	C25H43NaO6S
Citations	[1]Baghdasaryan A, et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mousecholangiopathy model by promoting biliary HCO3- output. Hepatology. 2011 Oct;54(4):1303-1312. [2]Rizzo G, et al. Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor andTGR5 agonist. Mol Pharmacol. 2010 Oct;78(4):617-630.
Smiles	C[C@H](CCOS(=O)(O[Na])=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1000403-03-1
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Autophagy; FXR; G protein-coupled Bile Acid Receptor 1
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	494.66
Product Description	INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively[1][2].
Manufacturer - Research Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL\|H2O : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy; GPCR/G Protein; Metabolic Enzyme/Protease
Clinical information	No Development Reported

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HY-12434-10mg-safety-datasheet.pdf