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OTS964 (hydrochloride)

OTS964 (hydrochloride)

Manufacturer	MedChem Express
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Specific against	other
Amount	10 mg
Item no.	HY-12467-10mg
Targets	TOPK; CDK; Apoptosis
CASRN	1338545-07-5
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor with an IC50 of 28 nM[1]. OTS964 hydrochloride is also a potent inhibitor of the cyclin-dependent kinase CDK11, which binds to CDK11B with a Kd of 40 nM[2].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	428.97
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : ≥ 83.33 mg/mL\|H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Apoptosis; CDK; TOPK
Isoform	CDK11
Pathway	Apoptosis; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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HY-12467-10mg-safety-datasheet.pdf